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Increased plasma DPP4 activities predict new-onset hyperglycemia in Chinese over a four-year period: possible

Tianpeng Zheng1, Attit Baskota2, Yun Gao2

  • 1Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Sichuan, P. R. China; Department of Endocrinology and Metabolism, Affiliated Hospital of Guilin Medical University, Guangxi, P. R. China.

Metabolism: Clinical and Experimental
|January 17, 2015
PubMed
Abstract

Insights

Elevated dipeptidyl peptidase-4 (DPP4) activity predicts increased risk of insulin resistance and hyperglycemia. This finding highlights DPP4

Area of Science:

  • Biochemistry
  • Endocrinology
  • Immunology

Background:

  • Dipeptidyl peptidase-4 (DPP4) is a proinflammatory cytokine.
  • DPP4 interacts with the IGF-II/M6P receptor.
  • The link between chronic inflammation and hyperglycemia is not fully understood.

Purpose of the Study:

  • To investigate the role of DPP4 in linking low-grade chronic inflammation and hyperglycemia.
  • To determine if DPP4 activity predicts the development of hyperglycemia.

Main Methods:

  • A prospective cohort study of 486 adults without hyperglycemia.
  • Measured DPP4 activity, IGF-II/M6P receptor, and inflammatory markers at baseline and after 4 years.
  • Used multiple linear regression and multivariable-adjusted models.

Main Results:

  • Baseline DPP4 activity predicted increased IGF-II/M6P receptor, inflammatory markers, and insulin resistance.
  • Higher DPP4 activity quartiles were associated with a 2.90-fold increased odds of incident hyperglycemia.
  • DPP4 activity improved prediction of new-onset hyperglycemia.

Conclusions:

  • DPP4 activity is a significant predictor of insulin resistance and hyperglycemia in apparently healthy individuals.
  • DPP4's proinflammatory role is implicated in hyperglycemia development.
  • Findings suggest potential therapeutic targets for hyperglycemia.
Keywords:
DPP4 activityHyperglycemiaInflammation

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