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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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Targeting the eIF4F translation initiation complex: a critical nexus for cancer development

Jerry Pelletier1, Jeremy Graff2, Davide Ruggero3

  • 1Department of Biochemistry, McGill University, Montreal, Québec, Canada. The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec, Canada. Department of Oncology, McGill University, Montreal, Québec, Canada. jerry.pelletier@mcgill.ca.

Cancer Research
|January 17, 2015
PubMed
Summary

Cancer cells exhibit elevated protein synthesis due to increased signaling to eukaryotic initiation factor 4F (eIF4F). Targeting eIF4F offers a potential strategy for developing novel cancer therapies.

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