Related Experiment Video
Updated: Apr 18, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in
Giorgia Savalli1, Zafar I Bashir2, E Clea Warburton3
1Departments of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Abstract:
Object-in-place (OiP) memory is critical for remembering the location in which an object was last encountered and depends conjointly on the medial prefrontal cortex, perirhinal cortex, and hippocampus. Here we examined the role of dopamine D1/D5 receptor neurotransmission within these brain regions for OiP memory. Bilateral infusion of D1/D5 receptor antagonists SCH23390 or SKF83566 into the medial prefrontal cortex, prior to memory acquisition, impaired OiP performance following a 5 min or 1 h delay. Retrieval was unaffected. Intraperirhinal or intrahippocampal infusions of SCH23390 had no effect. These results reveal a selective role for D1/D5 receptors in the mPFC during OiP memory encoding.
Related Concept Videos
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Role of Neurotransmitters in Memory
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Role of Cerebellum and Prefrontal Cortex in Memory
Olfaction
The olfactory receptors are embedded in the cilia of the...

