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The 2015 Nucleic Acids Research Database Issue and molecular biology database collection.

Michael Y Galperin1, Daniel J Rigden2, Xosé M Fernández-Suárez3

  • 1National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA nardatabase@gmail.com.

Nucleic Acids Research
|January 17, 2015
PubMed
Summary
This summary is machine-generated.

The 2015 Nucleic Acids Research Database Issue features 56 new and 115 updated molecular biology databases, categorized for easier navigation. Highlights include RNAcentral and cancer-related resources, expanding the NAR online collection.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • The 2015 Nucleic Acids Research (NAR) Database Issue presents a comprehensive overview of molecular biology databases.
  • It includes descriptions of 56 new databases and updates for 115 existing ones, published in NAR and other journals.

Discussion:

  • Databases are organized into eight subject categories for improved user navigation.
  • Notable new resources include RNAcentral for noncoding RNA, ValidatorDB for protein structures, SASBDB for small-angle scattering data, MoonProt for 'moonlighting' proteins, and ComPPI/Complex Portal for macromolecular complexes.
  • A significant number of cancer-related databases and resources for disease genomics, drug targets, and potential drugs are featured.

Key Insights:

  • The NAR online Molecular Biology Database Collection remains stable in size, with 74 new resources added and 77 obsolete sites removed.
  • The issue emphasizes the growing importance of specialized databases for various biological research areas.
  • Highlights showcase advancements in RNA databases, protein structure validation, macromolecular complex analysis, and disease-focused genomics.

Outlook:

  • Future database development will likely focus on community-driven resources and specialized data types.
  • Increased integration of cancer genomics and drug discovery databases is anticipated.
  • Continued curation and maintenance of the NAR Database Collection are crucial for researchers.