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Updated: Apr 18, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Keratinocytic vascular endothelial growth factor as a novel biomarker for pathological skin condition
Ok-Nam Bae1, Minsoo Noh2, Young-Jin Chun3
1College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 426-791.
Abstract:
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.
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