Related Experiment Video

Updated: Apr 18, 2026

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.3K

Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to

Srinivasa R Nagalla1, Caryn K Snyder1, John E Michaels1

  • 1DiabetOmics Inc, Beaverton, Oregon, USA.

Indian Journal of Endocrinology and Metabolism
|January 17, 2015
PubMed

Insights

A new maternal serum test shows promise for screening gestational diabetes mellitus (GDM). This multi-analyte panel detects 87% of GDM cases with a 1% false-positive rate, offering a potential improvement over current methods.

Area of Science:

  • Biochemistry
  • Clinical Diagnostics
  • Reproductive Medicine

Background:

  • Gestational diabetes mellitus (GDM) prevalence is rising globally, linked to the obesity and diabetes epidemic.
  • Untreated GDM poses risks to both mother and child, including pregnancy complications and future type-2 diabetes.
  • Current GDM screening via oral glucose tolerance tests are invasive and not widely accessible.

Purpose of the Study:

  • To develop and evaluate a novel multi-analyte maternal serum profile test for GDM screening.
  • To incorporate novel glycoprotein biomarkers alongside established GDM-associated markers.

Main Methods:

  • Development of a multi-analyte maternal serum profile test.
  • Inclusion of novel glycoprotein biomarkers and previously described GDM markers.
  • Evaluation of the test's performance in screening for GDM.

Main Results:

  • The multi-analyte panel achieved an 87% detection rate for GDM.
  • The test demonstrated a low false-positive rate of 1%.

Conclusions:

  • The developed multi-analyte serum profile test shows significant potential for accurate and accessible GDM screening.
  • This novel biomarker panel may offer a more efficient alternative to traditional GDM testing methods.

Keywords:
Gestational diabetesglycosylated fibronectinmaternal serum biomarker

More Related Videos

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death10:34

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death

Published on: December 21, 2016

6.9K
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

709

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.9K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.6K
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
4
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and...
2
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...
2
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K