Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

580
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
580
Stress and Mental Health01:30

Stress and Mental Health

1.6K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
1.6K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

885
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
885
Drug Dependence01:17

Drug Dependence

2.0K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
2.0K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.6K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.6K
Long-term Depression01:03

Long-term Depression

3.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Related to the Health of Ethnic Hispanic Children in the United States: Application of Multiple Disadvantage Model.

Journal of racial and ethnic health disparities·2026
Same author

Life satisfaction of older adult immigrants: an application of socioenvironmental framework for aging.

Aging & mental health·2026
Same author

Factors in the Mental Health of Children from Low-Income Families in the United States: An Application of the Multiple Disadvantage Model.

European journal of investigation in health, psychology and education·2025
Same author

Factors in Use of Mental Health Services by Older Adult Immigrants and Nonimmigrants.

Health & social work·2025
Same author

Frequent Alcohol Use of Adolescents in Low-Income Families: Application of the Multiple Disadvantage Model.

Substance use & misuse·2025
Same author

Risk and Protective Factors in Children Bullying Perpetration: Application of the Multiple Disadvantage Model.

Journal of interpersonal violence·2024

Related Experiment Video

Updated: Apr 18, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.8K

Depression and Substance Use: A Temporal-Ordered Model.

Celia C Lo1, Tyrone C Cheng2, Iván A de la Rosa3

  • 1a 1 Department of Sociology and Social Work, Texas Woman's University , Denton , Texas , USA.

Substance Use & Misuse
|January 17, 2015
PubMed
Summary

This study investigated the self-medication hypothesis, finding partial support. Depression and mental health care use were linked to substance use, influenced by social factors and prior substance use.

Keywords:
self-medication hypothesissubstance usetemporal-ordered model

More Related Videos

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.4K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.9K

Related Experiment Videos

Last Updated: Apr 18, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.8K
Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.4K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.9K

Area of Science:

  • Psychiatry
  • Public Health
  • Sociology

Background:

  • The self-medication hypothesis suggests individuals use substances to cope with mental health conditions.
  • Understanding the link between depression, mental health care, and substance use is crucial for public health interventions.

Purpose of the Study:

  • To empirically test the self-medication hypothesis.
  • To examine if diagnosed depression and mental health care utilization predict subsequent substance use.
  • To explore gender-specific relationships in this context.

Main Methods:

  • Longitudinal data from the Fragile Families and Child Wellbeing (FFCW) Study (nearly 5,000 births).
  • Analysis of 3,477 mothers and 2,096 fathers over 10 years (5 waves).
  • Utilized STATA generalized estimating equations for panel data analysis.

Main Results:

  • Partial evidence supported the self-medication hypothesis.
  • A link was found between depression, mental health care use, and substance use.
  • The relationship between substance use and mental health care was gender-specific.

Conclusions:

  • The self-medication hypothesis is only partially supported by this study's findings.
  • Co-occurrence of depression and substance abuse is influenced by social, demographic, and prior substance use factors.
  • Further research is needed to fully elucidate these complex relationships.