Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

371
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
371
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

886
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
886
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

391
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
391
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

513
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
513
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

929
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
929
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

1.9K
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remembering A Friend and Esteemed Colleague-Dr. Stanford T. Shulman.

Pediatric annals·2026
Same author

Confection Infection.

The Pediatric infectious disease journal·2024
Same author

Is It Really Acute Bacterial Sinusitis?

Pediatric annals·2023
Same author

Ten-Year Follow-up of 9-Valent Human Papillomavirus Vaccine: Immunogenicity, Effectiveness, and Safety.

Pediatrics·2023
Same author

Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial.

JAMA·2023
Same author

Tympanostomy Tubes or Medical Management for Recurrent Acute Otitis Media.

The New England journal of medicine·2021

Related Experiment Video

Updated: Apr 18, 2026

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.7K

Perpetually perplexing pediatric patients: it's complicated: part 2.

Stan L Block

    Pediatric Annals
    |January 17, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing complex pediatric illnesses requires sharp clinical skills. Thorough patient history, physical exams, and intuition are key to unraveling challenging pediatric cases.

    More Related Videos

    Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine
    06:09

    Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

    Published on: January 12, 2024

    1.1K
    Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
    15:18

    Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

    Published on: July 30, 2009

    18.8K

    Related Experiment Videos

    Last Updated: Apr 18, 2026

    Whole-body PET/MRI of Pediatric Patients: The Details That Matter
    10:02

    Whole-body PET/MRI of Pediatric Patients: The Details That Matter

    Published on: December 19, 2017

    15.7K
    Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine
    06:09

    Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

    Published on: January 12, 2024

    1.1K
    Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
    15:18

    Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

    Published on: July 30, 2009

    18.8K

    Area of Science:

    • Pediatric Medicine
    • Clinical Diagnostics

    Background:

    • Pediatric patients frequently present with complex and challenging medical conditions.
    • Effective diagnosis and treatment in pediatrics demand advanced clinical expertise.

    Observation:

    • Some pediatric cases appear mundane initially but can be highly complex.
    • Esoteric or convoluted illnesses can perplex even experienced clinicians.

    Findings:

    • Thorough patient history taking is crucial for diagnosing pediatric conditions.
    • Comprehensive physical examinations are essential for identifying underlying issues.
    • Developing a keen clinical intuition aids in managing difficult pediatric cases.

    Implications:

    • Mastering diagnostic and therapeutic skills is vital for pediatric healthcare providers.
    • A systematic approach combining data gathering and intuition improves patient outcomes.
    • Continuous learning and skill refinement are necessary for addressing diverse pediatric health challenges.