Related Experiment Video
Updated: Apr 18, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
Published on: December 6, 2014
Primary immunodeficiency diseases: a primer for PCPs
Elizabeth M Younger1, Kristin Epland, Annette Zampelli
1Elizabeth M. Younger is a nurse practitioner/program coordinator at Johns Hopkins, Baltimore, Md. Kristin Epland is an immunology nurse practitioner at Midwest Immunology Clinic, Plymouth, MN. Annette Zampelli is a medical science liaison at CSL Behring, King of Prussia, Pa. Mary K. Hintermeyer is a program coordinator/APNP at Children's Hospital, Primary Immune Deficiency Program, Milwaukee, Wis.
Insights
Primary care providers (PCPs) are crucial for diagnosing primary immunodeficiency diseases (PIDDs). This review offers essential information for PCPs managing patients with PIDDs post-diagnosis.
Area of Science:
- Immunology
- Primary Care Medicine
Background:
- Primary care providers (PCPs) are instrumental in the early identification of primary immunodeficiency diseases (PIDDs).
- Diagnosing PIDDs impacts ongoing patient care and management strategies within primary care settings.
Purpose of the Study:
- To provide essential information for PCPs on identifying and managing patients with PIDDs.
- To highlight the critical role of PCPs in the continuum of care for PIDD patients.
Main Methods:
- This is a review article.
- Information synthesis on PIDD identification and management for primary care.
Main Results:
- PCPs are key to PIDD diagnosis.
- PIDD diagnosis necessitates continued primary care involvement.
Conclusions:
- PCPs require specific knowledge to effectively manage PIDD patients.
- Enhanced PCP education can improve outcomes for individuals with PIDDs.
Abstract:
Primary care providers (PCPs) play a key role in identifying patients with primary immunodeficiency diseases (PIDDs). This diagnosis has implications for PCPs, as patients continue to require primary care and management after a PIDD diagnosis has been made. This review presents essential information for PCPs regarding PIDDs.
Related Concept Videos
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Infectious Diseases and Their Occurrence
Humoral Immune Responses

