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[Amyloid pseudotumor of the sciatic nerve].
J Y Gabet1, D Vital Durand, B Bady
1Service de Médecine Interne, Centre Hospitalier Lyon-Sud.
Revue Neurologique
|January 1, 1989
Summary
This study reports the first case of an amyloid pseudo-tumor in a peripheral nerve. The tumor, originating from immunoglobulin light chain (AL) amyloidosis, caused numbness and pain in the patient's leg.
Area of Science:
- Neurology
- Pathology
- Oncology
Background:
- Peripheral nerve tumors are rare and can present with diverse symptoms.
- Amyloidosis, characterized by abnormal protein deposits, typically affects visceral organs.
Observation:
- A 60-year-old man presented with right lower limb numbness and pain, indicative of nerve root lesions.
- CT revealed a 3.5 cm tumor at the emergence of the first right sacral root.
- Microscopic examination showed nerve fiber infiltration by eosinophilic material with Congo red positivity and green birefringence.
Findings:
- The amyloid deposits were identified as immunoglobulin light chain (AL) amyloidosis.
- Systemic investigation for amyloid deposits in other organs (heart, kidneys, digestive tract) was negative.
- This represents the first documented instance of an amyloid pseudo-tumor involving a peripheral nerve.
Implications:
- This case expands the known clinical spectrum of amyloidosis.
- Highlights the importance of considering amyloidosis in the differential diagnosis of peripheral nerve tumors.
- Suggests peripheral nerves can be a primary site for AL amyloid deposition, forming pseudo-tumors.