Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Apr 18, 2026

Learning Modern Laryngeal Surgery in a Dissection Laboratory

Learning Modern Laryngeal Surgery in a Dissection Laboratory

Published on: March 18, 2020

Is partial laryngectomy safe forever?

Kenneth Bagwell¹, Steven B Leder¹, Clarence T Sasaki¹

¹Yale School of Medicine, Department of Surgery, Section of Otolaryngology, New Haven, CT, United States.

American Journal of Otolaryngology

|January 18, 2015

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells.

International journal of molecular sciences·2021

Same author

Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo.

Cancers·2021

Same author

The temporal effects of topical NF-<i>κB</i> inhibition, in the <i>in vivo</i> prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model.

Oncotarget·2020

Same author

The in vivo preventive and therapeutic properties of curcumin in bile reflux-related oncogenesis of the hypopharynx.

Journal of cellular and molecular medicine·2020

Same author

The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights.

Cancers·2020

Same author

The Effect of NNK, A Tobacco Smoke Carcinogen, on the miRNA and Mismatch DNA Repair Expression Profiles in Lung and Head and Neck Squamous Cancer Cells.

Cells·2020

Function-preserving surgery for laryngeal cancer can lead to long-term swallowing problems. Late aspiration and dysphagia may necessitate completion laryngectomy years after initial treatment.

Area of Science:

Otolaryngology
Surgical Oncology
Swallowing Disorders

Background:

Function-preserving partial laryngectomy is an effective oncological treatment for select laryngeal cancers.
While short-term swallow function is often safe, long-term outcomes require further investigation.

Observation:

A retrospective case series identified 3 patients who underwent completion laryngectomy due to chronic aspiration.
These patients had successful oncological outcomes and initial swallow preservation for over 10 years post-partial laryngectomy.

Findings:

Late-onset dysphagia and chronic aspiration occurred 11-15 years after initial partial laryngectomy.
Two patients required completion laryngectomy, and a third is expected to need the procedure.

More Related Videos

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Published on: October 24, 2025

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Apr 18, 2026

Learning Modern Laryngeal Surgery in a Dissection Laboratory

Learning Modern Laryngeal Surgery in a Dissection Laboratory

Published on: March 18, 2020

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Published on: October 24, 2025

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

Implications:

Swallowing function after laryngeal surgery may decline over time, even with successful cancer control.
This highlights the need for extended post-operative follow-up and informed patient counseling regarding long-term risks.