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Safety Study of Transcranial Static Magnetic Field Stimulation (tSMS) of the Human Cortex
A Oliviero1, M C Carrasco-López1, M Campolo1
1FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain.
Background:
Transcranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability.
Objective:
The objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described.
Methods:
tSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests.
Results:
tSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected.
Conclusions:
Our data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.
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