Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies III: Computed Tomography

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood.

eLife·2026

Same author

When services start: A pilot study of parent perspectives on early intervention timing for very preterm infants.

Early human development·2026

Same author

Executive function and implications for the Preterm Behavioral Phenotype in very preterm children at age 9-10 years.

Journal of neurodevelopmental disorders·2026

Same author

Prenatal Substance Exposure and Birth Weight: Findings From the HEALthy Brain and Child Development Study.

Pediatrics·2026

Same author

BIBSNet: A deep learning baby image brain segmentation network for MRI scans.

Developmental cognitive neuroscience·2026

Same author

Simultaneous thermal and large field-of-view two-photon imaging enables optimization of signal-to-noise.

Neurophotonics·2026

Same journal

A neuroimaging meta-analysis on social impression formation of stable characteristics.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

An expanded cortical map of von Economo neurons in the human medial prefrontal cortex.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

For better and worse: neural self-partner overlap during social feedback is associated with relationship satisfaction and depressive symptoms.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Regions in the human inferior temporal gyrus are engaged in numerosity processing across visual stimulus categories.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Differentiation of cortical areas: effects of free energy minimization with broken symmetry.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Prior exposure to speech rapidly modulates cortical processing of high-level linguistic structure.

Cerebral cortex (New York, N.Y. : 1991)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 18, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Functional Imaging of the Developing Brain at the Bedside Using Diffuse Optical Tomography.

Silvina L Ferradal¹, Steve M Liao², Adam T Eggebrecht³

¹Department of Biomedical Engineering, Washington University, St Louis, MO, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.

Cerebral Cortex (New York, N.Y. : 1991)

|January 18, 2015

Summary

This summary is machine-generated.

High-density diffuse optical tomography (HD-DOT) offers a practical way to monitor infant brain function. This portable imaging method shows results comparable to MRI, enabling early brain development assessment in neonates.

Keywords:

developmental neuroimaging diffuse optical tomography functional magnetic resonance imaging infant neurodevelopment

More Related Videos

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

Mesoscopic Fluorescence Tomography for In-vivo Imaging of Developing Drosophila

Mesoscopic Fluorescence Tomography for In-vivo Imaging of Developing Drosophila

Published on: August 20, 2009

Related Experiment Videos

Last Updated: Apr 18, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

Mesoscopic Fluorescence Tomography for In-vivo Imaging of Developing Drosophila

Mesoscopic Fluorescence Tomography for In-vivo Imaging of Developing Drosophila

Published on: August 20, 2009

Area of Science:

Neuroscience
Medical Imaging
Developmental Biology

Background:

Conventional MRI studies reveal structural brain development but offer limited insight into early functional changes.
Resting-state functional connectivity MRI (fcMRI) can identify infant brain networks, but faces technical and logistical hurdles for early or repeated neonatal scans.
Assessing brain function in high-risk neonates is crucial for predicting neurodevelopmental outcomes.

Purpose of the Study:

To introduce a novel high-density diffuse optical tomography (HD-DOT) system for bedside functional brain imaging in infants.
To evaluate the system's ability to map functional brain development in neonates.
To compare HD-DOT findings with established fcMRI data.

Main Methods:

Development of an advanced HD-DOT system featuring improved cap design, ergonomics, and data analysis.
Bedside functional brain imaging of healthy, full-term neonates within the first days of life.
Co-registration and comparison of HD-DOT data with subject-matched fcMRI scans.

Main Results:

The developed HD-DOT system successfully enabled bedside mapping of functional brain development in neonates.
HD-DOT results showed strong congruence with co-registered, subject-matched fcMRI findings.
The observed patterns in HD-DOT data reflect typical brain development trajectories in healthy neonates.

Conclusions:

HD-DOT is a transformative and practical imaging modality for quantitative assessment of early functional brain development in infants.
This technology facilitates early and continuous monitoring, crucial for both normal and high-risk neonates.
HD-DOT offers a promising alternative to MRI for neonatal functional neuroimaging, overcoming previous limitations.