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Published on: August 21, 2017
Dermatomyositis as a presentation of neuromyelitis optica spectrum disorder
David Delman1, Xianming Peng1, Daniel C Zedek2
1Department of Neurology, 170 Manning Drive, Physician Office Building, Chapel Hill, NC 27599, USA.
Importance:
This is the first report of neuromyelitis optica spectrum disorder (NMOSD) associated with dermatomyositis (DM).
Report:
A 40year-old Caucasian female presented with 6months of worsening fatigue, rash, acute weakness worse in her lower extremities, and urinary retention. She was found to have both NMOSD and anti-melanoma differentiation-associated gene (MDA)5 positive DM with interstitial lung disease (ILD). She was treated aggressively and she regained her ability to ambulate.
Conclusion:
We recommend considering NMOSD in the differential diagnosis of patients with DM and other autoimmune disorders that also present with clinical signs of myelopathy.
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