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Updated: Apr 18, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.7K
Expert recommendations on treating psoriasis in special circumstances
J M Carrascosa1, I Belinchón2, P de-la-Cueva3
1Servei de Dermatologia, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.
Actas Dermo-Sifiliograficas
|January 18, 2015
Summary
Expert consensus on moderate to severe psoriasis management is now available. This guidance helps optimize biologic treatments, considering factors like drug levels, comorbidities, and pregnancy for better patient outcomes.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Extensive data exists on systemic and biologic therapies for moderate to severe psoriasis.
- Clinical application of this evidence presents challenges and necessitates expert consensus.
- Expert opinion is crucial for navigating complex treatment scenarios in psoriasis management.
Framework:
- Systematic literature review of 5 clinical scenarios related to psoriasis treatment.
- Online Delphi survey involving experienced dermatologists treating moderate to severe psoriasis.
- Structured expert discussion to address evidence gaps and clinical decision-making.
Implementation:
- Consensus reached on 37 out of 66 statements (56%) proposed in the survey.
- Identified appropriate intermittent therapeutic regimens and treatment de-escalation strategies.
- Recommended routine monitoring of drug and antidrug antibody levels for biologic therapies.
- Highlighted the influence of psoriatic arthritis and cardiovascular history on biologic selection (preference for anti-tumor necrosis factor agents).
- Emphasized tailored management for pregnant patients or those planning conception, considering drug half-life and disease severity.
Implications:
- Facilitates informed clinical decision-making in specific psoriasis scenarios.
- Optimizes biologic treatment strategies, potentially reducing costs.
- Guides the selection of appropriate therapies based on patient-specific factors and comorbidities.
- Provides a framework for managing psoriasis in special populations, such as pregnant individuals.
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