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Related Experiment Video

Updated: Apr 18, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Resection of thymoma should include nodal sampling.

Benny Weksler1, Arjun Pennathur2, Jennifer L Sullivan1

  • 1Division of Thoracic Surgery, University of Tennessee Health Science Center, Memphis, Tenn.

The Journal of Thoracic and Cardiovascular Surgery
|January 18, 2015
PubMed
Summary

Lymph node metastasis in thymoma significantly impacts survival and staging. Surgical resection of thymoma should include lymph node sampling to better understand prognosis.

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Area of Science:

  • Thoracic Surgery
  • Oncology
  • Pathology

Background:

  • Thymoma treatment involves surgical resection, but lymph node sampling guidelines are lacking.
  • The prognostic value of nodal metastases in thymoma remains unclear.

Purpose of the Study:

  • To investigate the prognostic implications of nodal metastases in thymoma patients.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results database.
  • Analyzed data from 442 patients who underwent thymoma resection with lymph node examination.
  • Examined the impact of nodal status on survival and staging.

Main Results:

  • 13.3% of patients had positive lymph nodes.
  • Node-positive patients had significantly shorter median survival (98 vs. 144 months, P = .013).

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Last Updated: Apr 18, 2026

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  • Nodal metastases independently predicted adverse survival (HR 1.945) and upstaged 80% of patients.

    • Conclusions:

    • Nodal status is a critical prognostic factor in thymoma.
    • Recommend including regional lymph node sampling in surgical therapy for thymoma.