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Aneuploidy in Lewy body diseases
Yue Yang1, Claire Shepherd1, Glenda Halliday1
1Neuroscience Research Australia, Randwick, New South Wales, Australia; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.
Neurobiology of Aging
|January 18, 2015
Summary
Increased neuronal DNA content is linked to brain cell degeneration in Lewy body diseases, particularly associated with Alzheimer
Area of Science:
- Neuroscience
- Neuropathology
- Cell Biology
Background:
- Increased DNA content in neurons is a known factor in Alzheimer's disease-related neurodegeneration.
- This phenomenon has not been previously investigated in Lewy body diseases (LBDs).
Purpose of the Study:
- To evaluate neuronal and total cell DNA content and cell numbers in brain regions affected by LBDs.
- To correlate DNA content changes with the severity of Lewy body and Alzheimer pathologies in LBDs.
Main Methods:
- Employed stereological principles for cell counting.
- Utilized flow cytometry to assess DNA content.
- Conducted standard histopathological examination of brain tissue.
Main Results:
- Observed increased neuronal DNA content across all examined brain regions in LBDs.
- In the substantia nigra, elevated DNA content correlated with neuronal loss.
- In the cortex and hippocampus, increased DNA content was associated with Alzheimer pathologies, not Lewy body deposition.
Conclusions:
- Increased neuronal DNA content is a common finding in affected brain regions of Lewy body diseases.
- This increase is linked to distinct pathologies: neuronal loss in the substantia nigra and Alzheimer pathologies in the cortex/hippocampus.
- Elevated neuronal DNA content may enhance susceptibility to neurodegeneration and Alzheimer pathologies in LBDs.
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