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Related Experiment Video

Updated: Apr 18, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Hollow polymer microneedles array resistance and insertion tests.

Marion Sausse Lhernould1, Michel Deleers1, Alain Delchambre1

  • 1Université Libre de Bruxelles - Bio Electro and Mechanical Systems, Av. F.D. Roosevelt 50, CP165/56, 1050 Brussels, Belgium.

International Journal of Pharmaceutics
|January 18, 2015
PubMed
Summary

This study tested polymer microneedle arrays for transdermal drug delivery. Results show the arrays are highly resistant to insertion, but insertion parameters require optimization for effective skin penetration.

Keywords:
InsertionMembrane penetrationMicroneedlesMicroneedles arrayTransdermal drug delivery

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutics

Background:

  • Microneedles are a promising future transdermal drug delivery system.
  • Effective insertion into biological membranes remains a significant challenge.
  • Standardized testing methods are crucial for microneedle array development.

Purpose of the Study:

  • To evaluate the insertion capabilities of a novel hollow polymer microneedle array.
  • To assess microneedle array performance using a standardized membrane model.
  • To identify key parameters for optimizing microneedle insertion.

Main Methods:

  • Utilized a recently proposed model membrane and test method for microneedle insertion.
  • Tested a 4x4 hollow polymer microneedle array against a folded Parafilm® membrane.
  • Performed insertion tests varying force, speed, and holding time.

Main Results:

  • The polymer microneedle array demonstrated exceptional resistance to insertion forces.
  • The array maintained its integrity and sharpness even after multiple insertions.
  • Parafilm® showed high similarity to porcine skin in insertion tests.

Conclusions:

  • Optimizing insertion force, speed, and holding time is critical for reliable microneedle penetration.
  • Further research is needed to achieve efficient and consistent insertion depths of at least 500μm.
  • This study provides valuable data for advancing microneedle array technology for transdermal administration.