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Updated: Apr 18, 2026
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced
Rodrigo Gonzalez Bonhin1, Vanessa Brito Campoy Rocha1, Guilherme Machado de Carvalho1
1Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Introduction:
Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor aggressiveness, as evidenced by the presence of cervical lymphatic metastases.
Objectives:
To evaluate the expression of the vascular endothelial growth factor marker in non-glottic advanced squamous cell carcinoma of the larynx (T3/T4) and correlate it with the presence of cervical lymph node metastases.
Methods:
Retrospective clinical study and immunohistochemical analysis of vascular endothelial growth factor through the German scale of immunoreactivity in products of non-glottic squamous cell carcinomas.
Results:
This study analyzed 15 cases of advanced non-glottic laryngeal tumors (T3/T4), four of which exhibited cervical lymphatic metastases. There was no correlation between vascular endothelial growth factor expression and the presence of cervical metastases.
Conclusion:
Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases.
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