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Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

Investigating a common approach to DNA profile interpretation using probabilistic software.

Stuart Cooper¹, Catherine McGovern¹, Jo-Anne Bright¹

¹ESR, Private Bag 92021, Auckland 1142, New Zealand.

Forensic Science International. Genetics

|January 18, 2015

Summary

Forensic DNA profile interpretation using STRmix™ software shows improved concordance among analysts. However, challenges remain in consistently determining the number of contributors in complex DNA samples.

Keywords:

Forensic DNA interpretation Mixed DNA profile STRmix™Standardisation

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Area of Science:

Forensic Science
Genetics
Molecular Biology

Background:

Standardization of DNA profile interpretation is crucial for forensic laboratories.
STRmix™ is a probabilistic software adopted for DNA profile interpretation in Australia and New Zealand.

Purpose of the Study:

To examine the concordance in DNA profile interpretation using STRmix™.
To assess inter-laboratory and inter-analyst agreement across international forensic laboratories.

Main Methods:

Three crime-related DNA profiles of varying complexity were analyzed.
Twenty analysts from twelve international laboratories interpreted the profiles using STRmix™ software.

Main Results:

Probabilistic software like STRmix™ has increased concordance in DNA profile interpretation.
Differences in interpretation persist, especially in objectively assigning the number of contributors.

Conclusions:

While STRmix™ enhances consistency, further refinement is needed for objective contributor number assignment.
Standardization efforts must address interpretation nuances for complex forensic DNA profiles.