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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Antibiotic use in Albania between 2011 and 2012
Iris Hoxha1, Admir Malaj, Ledjan Malaj
1Faculty of Pharmacy, University of Medicine, Tirana, Albania. ir_hoxha@hotmail.com.
Antibiotic use in Albania decreased between 2011-2012, but remained high compared to reimbursed data. This highlights potential issues with antibiotic misuse and prescription quality for policymakers to investigate.
Area of Science:
- Pharmacology and Public Health
- Microbial Resistance Studies
Background:
- Albania faces rising antibiotic misuse and microbial resistance.
- No prior comprehensive studies analyzed national antibiotic consumption.
Purpose of the Study:
- To quantify overall antibiotic use in Albania from 2011-2012.
- To establish a baseline for future antibiotic stewardship initiatives.
Main Methods:
- Utilized World Health Organization guidelines for standardized measurement.
- Analyzed ambulatory and hospital sector data using Defined Daily Dose per 1,000 inhabitants per day (DID).
- Classified antibiotics via the Anatomical Therapeutic Chemical system.
Main Results:
- Total antibiotic consumption decreased from 24.25 to 20.66 DID between 2011 and 2012.
- Penicillins were the most utilized class, followed by decreasing tetracycline use and increasing macrolides and quinolones.
- Overall antibiotic use significantly exceeded reimbursed levels (3.17 DID in 2011, 2.79 DID in 2012).
Conclusions:
- Findings provide crucial data for Albanian policymakers on antibiotic prescription quality.
- Data suggest factors influencing out-of-pocket and potentially inappropriate antibiotic prescriptions require further investigation.
- Highlights the need for comparative international analysis of antibiotic usage patterns.
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