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Prefrontal Cortical Inactivations Decrease Willingness to Expend Cognitive Effort on a Rodent Cost/Benefit

Jay G Hosking1, Paul J Cocker1, Catharine A Winstanley1

  • 1Department of Psychology, University of British Columbia, Vancouver, Canada.

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Summary
This summary is machine-generated.

The prefrontal cortex (PFC) is crucial for expending mental effort, with its prelimbic (PL) and infralimbic (IL) regions regulating attention and impulsivity. Inactivating these areas impairs effort-based decision-making, suggesting a focus on cognitive resources for therapeutic interventions.

Keywords:
animal modelcortico-limbic-striatal circuitsinfralimbic cortexmental effortprelimbic cortex

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Decision Science

Background:

  • Effort-based decision-making is vital for success, requiring cognitive resources like attention.
  • Previous research indicated PFC involvement in mental effort but not physical effort-based choice.

Purpose of the Study:

  • To investigate the role of the prelimbic (PL) and infralimbic (IL) regions of the prefrontal cortex (PFC) in mental effort-based decision-making using the rat Cognitive Effort Task (rCET).

Main Methods:

  • The study employed the rCET, where rats chose between easy, low-demand/low-reward trials and difficult, high-demand/high-reward trials.
  • Temporary inactivation of PL and IL regions of the PFC was performed to observe effects on behavior.

Main Results:

  • Inactivation of PL and IL decreased willingness to expend mental effort and increased distractibility.
  • PL inactivation primarily affected attentional performance, while IL inactivation increased motor impulsivity.

Conclusions:

  • The PFC, specifically PL and IL regions, plays a critical role in regulating attentional resources for effort-based decision-making.
  • Deficits in effort expenditure may be addressed by targeting cognitive resources rather than the decision-making process itself.