Related Experiment Video
Updated: Apr 18, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
Published on: March 27, 2018
Applying lean principles to continuous renal replacement therapy processes
C Brett Benfield1, Philip Brummond2, Andrew Lucarotti2
1C. Brett Benfield, Pharm.D., is Postgraduate Year 1 Ambulatory Administrative Resident, Fairview Pharmacy Services, Minneapolis, MN; at the time of writing he was Student Pharmacist, University of Michigan College of Pharmacy (UMCP), Ann Arbor. Philip Brummond, Pharm.D., M.S., is Director of Pharmacy, Froedtert Hospital, Milwaukee, WI; at the time of writing he was Pharmacy Assistant Director, University of Michigan Health System (UMHS), Ann Arbor. Andrew Lucarotti, Pharm.D., is Pharmacist-Generalist UMHS, and Adjunct Clinical Instructor, UMCP. Maria Villarreal, CPhT, is Certified Pharmacy Technician; Adam Goodwin, CPhT, is Certified Pharmacy Technician; Rob Wonnacott, RN, is Critical Care Nurse; Cheryl Talley, RN, is Critical Care Nurse; and Michael Heung, M.D., M.S., is Medical Director, Inpatient Dialysis Programs, Department of Medicine, Division of Nephrology, UMHS. cbenfie1@fairview.org.
Applying lean principles to continuous renal replacement therapy (CRRT) reduced medication waste and improved workflow efficiency. This initiative saved over $70,000 annually by decreasing discarded CRRT solution bags.
Area of Science:
- Nephrology
- Healthcare Management
- Process Improvement
Background:
- Continuous renal replacement therapy (CRRT) processes can be prone to medication waste.
- A significant amount of CRRT solution was being discarded in an academic medical center.
- Optimizing CRRT workflows is crucial for efficiency and cost savings.
Purpose of the Study:
- To describe the application of lean principles to CRRT processes.
- To examine the workflow for CRRT preparation and implement an intervention.
- To reduce medication waste and improve staff satisfaction in CRRT.
Main Methods:
- Lean principles were applied to analyze the CRRT preparation workflow.
- An educational program was developed to enhance communication between nursing and pharmacy.
- The CRRT solution reordering workflow was shifted from nurses to pharmacy technicians.
Main Results:
- A manual audit revealed 133 discarded 5-L bags of CRRT solution over six weeks.
- The mean number of CRRT solution bags dispensed per day of CRRT decreased substantially post-intervention.
- Projected annual cost savings exceeded $70,000 due to reduced solution waste.
Conclusions:
- Lean principles effectively identified and reduced medication waste in the CRRT workflow.
- Shifting workload to pharmacy technicians improved CRRT workflow efficiency.
- Staff satisfaction increased following the implementation of lean principles and workflow changes.
Related Concept Videos
Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Acute Kidney Injury V: Interprofessional Care
Hemodialysis III: Nursing Management
Chronic Kidney Disease IV: Nursing Management
Acute Kidney Injury VI: Nursing Management

