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Related Concept Videos

The Placebo Effect01:54

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The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
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Blind Procedures02:07

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
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Related Experiment Video

Updated: Apr 18, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
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Hyperbaric medicine and the placebo effect.

Michael H Bennett1

  • 1University of New South Wales and Prince of Wales Hospital, Department of Diving and Hyperbaric Medicine Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia, Mobile: +64-(0)411-483-491,

Diving and Hyperbaric Medicine
|January 19, 2015
PubMed
Summary

Placebos can trigger physiological changes, even when patients know they are inactive. This raises questions about hyperbaric medicine, where low-pressure air might be therapeutic, not just a sham.

Keywords:
Placeboevidencegeneral interesthyperbaric researchresearch

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Area of Science:

  • Medical research
  • Pharmacology
  • Hyperbaric medicine

Background:

  • Placebo use in medicine and research is common, yet mechanisms remain unclear.
  • Placebo administration can elicit measurable physiological responses, such as endorphin release.
  • Placebo effects persist even when patients are aware of the intervention's inactive nature.

Purpose of the Study:

  • To explore the nature of placebo and participation effects.
  • To discuss the implications for hyperbaric oxygen therapy (HBOT).

Main Methods:

  • Literature review on placebo effects.
  • Analysis of the role of sham interventions in clinical research.
  • Examination of the debate surrounding low-pressure air in hyperbaric medicine.

Main Results:

  • Placebo effects are complex and not fully understood.
  • The distinction between active intervention and sham is challenged in hyperbaric settings.
  • 131 kPa of air is debated as a potential therapeutic agent rather than a placebo.

Conclusions:

  • Understanding placebo and participation effects is crucial for interpreting HBOT results.
  • Rethinking the definition of sham interventions in hyperbaric medicine is necessary.
  • Further research is needed to clarify the therapeutic potential of low-pressure air in HBOT.