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Viscosupplementation: techniques, indications, results.

V Legré-Boyer1

  • 1Institut de l'Appareil Locomoteur Nollet, 23, rue Brochant, 75017 Paris, France; Service de Rhumatologie, Hôpital Universitaire Pitié-Salpêtrière, 72013 Paris, France; Hôpital américain de Paris, 92200 Neuilly-sur-Seine, France.

Orthopaedics & Traumatology, Surgery & Research : OTSR
|January 19, 2015
PubMed
Summary
This summary is machine-generated.

Hyaluronic acid (HA) injections offer moderate pain relief and functional improvement for osteoarthritis, potentially delaying joint replacement. Optimal use requires careful patient selection, particularly for moderate knee osteoarthritis without swelling.

Keywords:
ChondropathyHyaluronic acidHylanOsteoarthritisSodium hyaluronateViscosupplementation

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Area of Science:

  • Orthopedics
  • Rheumatology
  • Pharmacology

Background:

  • Osteoarthritis (OA) is a prevalent joint disease.
  • Viscosupplementation with hyaluronic acid (HA) is a common local treatment for OA.
  • Various HA derivatives exist with differing evidence.

Purpose of the Study:

  • To review the efficacy and optimal use of HA viscosupplementation for osteoarthritis.
  • To discuss the benefits, limitations, and appropriate patient selection for HA injections.

Main Methods:

  • Systematic review of existing literature on HA viscosupplementation.
  • Analysis of clinical trial data regarding pain, function, and responder rates.
  • Evaluation of HA efficacy across different joints and OA phenotypes.

Main Results:

  • HA viscosupplementation shows moderate efficacy (20%) in reducing pain and improving function in knee OA.
  • High responder rates (60-70%) are observed, with sustained effects for 6-12 months.
  • Reduced need for analgesics and potential delay of joint replacement are noted.

Conclusions:

  • HA injections are effective for chronic moderate knee OA, especially without joint swelling.
  • Efficacy varies by joint; promising in ankle and shoulder OA, less so in hip OA.
  • Further research is needed to define optimal patient profiles and treatment protocols.