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[Protective effect of epigallocatechin gallate against sperm abnormality in mice]
Liu-Cai Sui1, Yi-Feng Ge, Juan-Juan Xu
1Nanjing General Hospital of Nanjing Military Region, Jiangsu, China. suiliucai@gmail.com
Objective:
To investigate the protective effect of epigallocatechin gallate (EGCG) on mouse sperm in vivo.
Methods:
A total of 64 six-week-old male Kuming mice were randomly divided into eight groups of equal number to be treated with normal saline (negative control), Cyclophosphamide (CP) at 30 mg/kg (positive control), and CP followed by EGCG (experimental) at 20, 40, and 80 mg/kg, respectively, given every other day for 10 days. At 4 and 5 weeks after treatment, the bilateral testes of the mice were harvested for examination of sperm abnormality.
Results:
EGCG did not increase the rate of CP-induced sperm abnormality in the mice, but reduced it instead with the prolonged time of treatment.
Conclusion:
EGCG protects mouse sperm in vivo.
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