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Updated: Apr 18, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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[Updated treatment of castration-resistant prostate cancer]

Song Xu1, Zheng-Yu Zhang

  • 1Department of Urology, Nanjing General Hospital of Nanjing Military Region, Jiangsu, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|January 20, 2015
PubMed

Insights

Most prostate cancer patients develop castration-resistant prostate cancer (CRPC) after initial treatment. This review explores new therapeutic agents offering improved survival options for advanced CRPC.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Prostate cancer frequently progresses to castration-resistant prostate cancer (CRPC) after initial castration therapy.
  • Limited therapeutic options exist to improve survival for patients with advanced CRPC.

Purpose of the Study:

  • To provide an overview of novel therapeutic agents for castration-resistant prostate cancer.
  • To highlight recently approved drugs and those in advanced clinical trials for CRPC treatment.

Main Methods:

  • Literature review of recent clinical trials and approved therapies for CRPC.
  • Analysis of various action mechanisms of new CRPC drugs.

Main Results:

  • Several new drugs targeting CRPC with diverse mechanisms have been approved.
  • Additional promising agents are undergoing advanced clinical trials.

Conclusions:

  • Emerging therapeutic strategies offer new hope for improving outcomes in castration-resistant prostate cancer.
  • Ongoing research and development are crucial for advancing CRPC treatment.

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