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Updated: Apr 18, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for
Steven R Caliari1, Daniel W Weisgerber, William K Grier
1Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 104 RAL, 600 S. Mathews Ave., Urbana, IL, 61801, USA.
Abstract:
A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

