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Synthesis and biological activity of dansyl thymidines
G M Bonora1, G Palù, C Dos Santos
1Centro di Studi Sui Biopolimeri, C.N.R., Dipartimento di Chimica Organica, Università di Padova.
Farmaco (Societa Chimica Italiana : 1989)
|October 1, 1989
Abstract:
The synthesis of thymidines selectively dansylated in the 3'- and 5'-positions is reported. The biological investigation showed that these fluorescent nucleosides behave as competitive inhibitors of thymidine kinase (TK) from herpes simplex virus (HSV) and are endowed with a certain degree of antiviral activity against HSV-2 and HSV-1.