[Localization of human lung cancer xenografts in nude mice using monoclonal antibody]

Radiolabeled monoclonal antibodies to human lung cancer were injected into nude mice bearing xenografts; and the biodistribution and tumor localization were studied. Xenografts were able to concentrate radioiodinated McAb. Radioactivities of tumor which were 5.09, 5.79 and 7.57% dose/g respectively 3-5 days after injection were higher than those of blood or organ. Tumor/blood ratios were 1.82-2.36 whereas tumor/organ ratios were more than 2. The localization indices of two McAbs were 3.4-5.6 and less than 1.5 in normal organs. The xenografts were visualized after injection of radiolabeled McAbs. These results have shown that anti-human lung cancer McAbs can specifically localize on xenografts in nude mice and it is possible to use them clinically for imaging of lung cancer.