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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
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Inflammation in cold complex regional pain syndrome
M Dirckx1, D L Stronks1, E A M van Bodegraven-Hof1
1Center for Pain Medicine, Erasmus MC, Rotterdam, The Netherlands.
Acta Anaesthesiologica Scandinavica
|January 20, 2015
Summary
This study investigated inflammation in complex regional pain syndrome (CRPS). Results indicate that pro-inflammatory cytokine levels do not differ between warm, cold, and intermediate CRPS types, suggesting inflammation may be involved in cold CRPS.
Area of Science:
- Pain Medicine
- Neurology
- Immunology
Background:
- Complex Regional Pain Syndrome (CRPS) presents with temperature asymmetry between affected and contralateral limbs.
- Warm CRPS is typically associated with inflammation, while cold CRPS is less understood.
- Previous observations suggest inflammation might underlie cold CRPS, potentially masked by vasomotor disturbances.
Purpose of the Study:
- To investigate the role of inflammation in different CRPS subtypes.
- To test the hypothesis that inflammation is present even in cold CRPS.
Main Methods:
- Retrospective analysis of a CRPS patient database.
- Classification of CRPS into cold, intermediate, and warm types.
- Measurement of pro-inflammatory cytokines, Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α), in affected and contralateral extremities.
Main Results:
- No significant difference in the bilateral difference of IL-6 and TNF-α levels was found among cold, intermediate, and warm CRPS patients.
- Cytokine levels did not distinguish between the CRPS subtypes.
Conclusions:
- The study's findings suggest that inflammation may play a role in cold CRPS.
- Further research is needed to elucidate the mechanisms of inflammation in different CRPS phenotypes.
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