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Direct extraction and assay of collagenase from human osteoarthritic articular cartilage
A Blanckaert1, B Mazières, Y Eeckhout
1Laboratoire de Pathologie Ostéo-articulaire, CHU Rangueil, Toulouse, France.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 31, 1989
Abstract:
A method has been developed for the direct extraction of collagenase from small quantities (5 mg) of human osteoarthritic articular cartilage. The enzyme, which was not detected in normal cartilage, was entirely in a latent form and demonstrated typical properties of mammalian collagenase after activation by trypsin.