Related Experiment Video

Updated: Oct 13, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.8K

[Multivariate analysis on the association between acquired multi-drug resistant organism infection and

Wensen Chen1, Songqin Li1, Suming Zhang1

  • 1The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|January 20, 2015
PubMed
Abstract

Insights

Patients with multi-drug resistant organisms (MDRO) have a significantly higher risk of developing ventilator-associated pneumonia (VAP). This increases hospital stays and intensive care unit (ICU) duration, highlighting the need for control measures.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Hospital Epidemiology

Background:

  • Ventilator-associated pneumonia (VAP) is a significant concern in intensive care units (ICUs).
  • Multi-drug resistant organisms (MDROs) pose a growing threat to patient safety and treatment efficacy.

Purpose of the Study:

  • To investigate the association between acquired multi-drug resistant organisms (MDRO) and ventilator-associated pneumonia (VAP).
  • To determine the risk of VAP in ICU patients colonized or infected with MDROs.

Main Methods:

  • A nested case-control study design was employed.
  • Real-time hospital infection monitoring data from 2013 was analyzed.
  • Logistic multivariable regression models were used to assess the association.

Main Results:

  • Patients with MDRO colonization or infection had a 3.05-fold increased risk of VAP (adjusted OR = 4.05).
  • MDRO-positive patients experienced significantly longer hospital stays, ICU stays, and mechanical ventilation durations.
  • Increased antimicrobial drug use was also noted in MDRO-positive patients.

Conclusions:

  • MDRO colonization and infection are significant risk factors for VAP.
  • Effective MDRO control strategies are crucial for improving patient safety and outcomes in ICUs.
  • Prolonged hospitalization and ICU stay are associated with MDRO-positive VAP cases.

More Related Videos

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

9.6K
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.7K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...