Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Early prediction of joint space narrowing in rheumatoid arthritis using AI-quantified bilateral joint space asymmetry on hand radiography.

Japanese journal of radiology·2026

Same author

Diagnostic Performance of Quantitative T1rho MRI for the Assessment of Disease Activity in Relapsing-Remitting Multiple Sclerosis.

Academic radiology·2026

Same author

Effects of achieving simple disease activity index remission on joint space outcomes progression in early rheumatoid arthritis: an exploratory study using high-resolution peripheral quantitative computed tomography.

Therapeutic advances in musculoskeletal disease·2026

Same author

Differentiation of physiological from pathological bone erosions in rheumatoid arthritis: an 8-year HR-pQCT study of the second metacarpal head.

Annals of the rheumatic diseases·2026

Same author

Reply to "Ramp Lesions of the Knee and Posteromedial Meniscal Root Lesions".

AJR. American journal of roentgenology·2026

Same author

Poor Bone Health Associated with Reduced Cerebral Perfusion and Brain Volume in Older Adults.

Diagnostics (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Apr 18, 2026

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

Rapid increase in marrow fat content and decrease in marrow perfusion in lumbar vertebra following bilateral

Yi-Xiáng J Wáng¹, James F Griffith¹, Min Deng¹

¹Department of Imaging & Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China.

Korean Journal of Radiology

|January 20, 2015

Summary

Bilateral oophorectomy rapidly reduces bone mineral density (BMD) and marrow blood perfusion while increasing marrow fat. These changes in bone health markers occur quickly after surgical removal of ovaries.

Keywords:

Blood perfusion Bone mineral density Magnetic resonance Marrow fact content Oophorectomy

More Related Videos

Novel Mini-open Transforaminal Lumbar Interbody Fusion

Novel Mini-open Transforaminal Lumbar Interbody Fusion

Published on: June 6, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

Related Experiment Videos

Last Updated: Apr 18, 2026

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

Novel Mini-open Transforaminal Lumbar Interbody Fusion

Novel Mini-open Transforaminal Lumbar Interbody Fusion

Published on: June 6, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

Area of Science:

Bone Metabolism
Reproductive Endocrinology
Medical Imaging

Background:

Bilateral oophorectomy causes bone mineral density (BMD) loss.
Reduced BMD correlates with increased bone marrow fat and decreased perfusion.
The timing of these post-surgical changes is not well-established.

Purpose of the Study:

To determine the timeline of BMD, marrow fat, and perfusion changes after bilateral oophorectomy.
To investigate the early effects of surgical menopause on bone microenvironment.

Main Methods:

Six women undergoing hysterectomy and bilateral salpingo-oophorectomy were studied.
Quantitative CT for BMD, MR spectroscopy for fat fraction (FF), and dynamic contrast-enhanced MRI for perfusion were used.
Measurements were taken pre-surgery and at 3, 9, and 21 months post-surgery.

Main Results:

A significant decrease in BMD (12.5%) and perfusion (23.6% enhancement slope) occurred within 3 months.
Bone marrow fat fraction (FF) increased significantly (92.2%) within 3 months.
These changes continued at a slower rate over 21 months, with statistically significant trends (p < 0.05).

Conclusions:

Bilateral oophorectomy rapidly induces significant reductions in lumbar BMD.
Surgical menopause leads to a rapid increase in bone marrow fat content.
Marrow blood perfusion significantly decreases following oophorectomy.