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Imaging benzodiazepine receptors in the human brain by single photon emission computed tomography (SPECT)
K Höll1, E Deisenhammer, J Dauth
1Department of Neuronuclear Medicine and Neurophysiology, Wagner-Jauregg Hospital, Linz, Switzerland.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1989
Abstract:
Recently, [123I]Ro16-0154 has been introduced as a potential benzodiazepine (BZD) receptor imaging tracer for SPECT. We investigated the biodistribution of [123I]Ro16-0154 in humans and compared it with the animal data. There was a rapid and high 123I-uptake in the brain comparable to rCBF. In the following images, however, regionally different changes were observed, resulting in a subsequent intracerebral retention parallel to the known distribution of BZD receptors. The results suggest that [123I]Ro16-0154 is of potential clinical use as a BZD receptor imaging agent.