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Related Experiment Video

Updated: Apr 18, 2026

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
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CyBorD induction therapy in clinical practice.

N Areethamsirikul1, E Masih-Khan1, C-M Chu1

  • 1Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Bone Marrow Transplantation
|January 20, 2015
PubMed
Summary
This summary is machine-generated.

Cyclophosphamide, bortezomib, and dexamethasone (CyBorD) is an effective induction regimen for multiple myeloma. Real-world data show high response rates and survival, comparable to clinical trials, with good tolerability.

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Area of Science:

  • Hematology
  • Oncology
  • Clinical Therapeutics

Background:

  • Cyclophosphamide, bortezomib, and dexamethasone (CyBorD) is a widely used induction regimen for multiple myeloma.
  • Phase 2 data suggest high efficacy, but real-world effectiveness requires evaluation.

Purpose of the Study:

  • To assess the real-world effectiveness and safety of the CyBorD regimen.
  • To compare outcomes with existing clinical trial data.

Main Methods:

  • Retrospective review of 109 newly diagnosed multiple myeloma patients treated with CyBorD outside of a clinical trial.
  • Evaluation of response rates (ORR, ≥VGPR), stem cell collection success, survival, and toxicity.

Main Results:

  • High overall response rate (95%) and ≥VGPR (66%) after induction, comparable to Phase 2 studies.
  • Excellent outcomes post-autologous stem cell transplant (ORR 98%, ≥VGPR 79%).
  • 2-year overall survival of 95.3%; concurrent plasmacytoma was a negative prognostic factor.

Conclusions:

  • CyBorD is a convenient, well-tolerated, and highly effective induction regimen in real-world practice.
  • It demonstrates comparable efficacy to clinical trials and supports successful autologous stem cell transplantation.
  • Minimal severe toxicity was observed, highlighting its favorable safety profile.