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Updated: Apr 18, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Scleral lens tolerance after corneal cross-linking for keratoconus
Esther-Simone Visser1, Nienke Soeters, Nayyirih G Tahzib
1*MSc †BOptom ‡MD, PhD Visser Contact Lens Practice, Nijmegen, The Netherlands and Visser Contact Lens Practice, and Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands (E-SV); Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands (NS); and Zonnestraal Eye Hospital Amersfoort, Amersfoort, The Netherlands (NGT).
Purpose:
Subjective and objective evaluation of scleral lens tolerance and fitting before and after corneal cross-linking (CXL) for progressive keratoconus.
Methods:
In this prospective cohort, evaluations were made of 18 unilateral eyes in patients who underwent CXL and had been wearing scleral lenses before the procedure. All the patients gave informed consent; they were able to cooperate with the study, were eligible for CXL, had been wearing well-fitting scleral lenses for at least 3 months, and had no other active ocular disease. Data were collected before and 1 year after CXL. Outcome measures were changes in clinical and subjective scleral lens performance. The following components were studied: scleral lens corrected distance visual acuity, scleral lens specifications, scleral lens fit, wearing time, and subjective measures on visual analogue scale questionnaires (1 to 100 mm).
Results:
There was no significant change in scleral lens corrected distance visual acuity (p = 0.632). Sixty-one percent of eyes needed a scleral lens fit and/or power change. Wearing time (median, 16 hours per day) and subjective tolerance were found to be stable.
Conclusions:
Scleral lens tolerance after CXL appeared to be stable.
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