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Prognostic factors in crescentic glomerulonephritis: a single-center experience
Ramazan Ozturk, Ezgi Coskun Yenigun1, Fatih Dede
1Ankara Numune Education and Research Hospital, Department of Nephrology, Ankara, Turkey. drezgi_76@hotmail.com.
Iranian Journal of Kidney Diseases
|January 21, 2015
Summary
Crescentic glomerulonephritis (CGN) is a severe kidney disease. Early diagnosis and treatment are crucial, as high creatinine, low urine output, and more crescentic glomeruli indicate a poor prognosis and need for dialysis.
Area of Science:
- Nephrology
- Pathology
Background:
- Crescentic glomerulonephritis (CGN) is a rapidly progressive and often fatal kidney disease.
- Prompt diagnosis and immediate treatment are essential to improve patient outcomes and prevent end-stage renal disease.
Purpose of the Study:
- To investigate the clinical and demographic factors associated with renal prognosis in patients diagnosed with CGN.
- To identify predictors of progression to end-stage renal disease in CGN patients.
Main Methods:
- Retrospective analysis of 41 CGN patients treated at Ankara Numune Education and Research Hospital.
- Patients were divided into dialysis-dependent and non-dialysis groups for comparison.
- Evaluated demographic data, clinical features, and kidney biopsy findings at diagnosis.
Main Results:
- The dialysis-dependent group exhibited higher serum creatinine, greater percentage of glomeruli with crescents, and a higher incidence of oliguria-anuria.
- Dialysis-dependent patients were more likely to require dialysis at admission and had a longer delay in treatment initiation.
- Key indicators for poor prognosis at admission included serum creatinine > 4.2 mg/dL and > 63% crescentic glomeruli.
Conclusions:
- Renal prognosis in CGN patients is generally poor.
- Factors such as delayed hospital admission, severity of renal insufficiency, presence of oliguria-anuria, need for dialysis, and high percentage of crescentic glomeruli are strongly associated with progression to end-stage renal disease.
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