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Interferon gamma release assays and tubercolin skin test performance in different settings of HIV immunodeficiency
Roberto Parrella1, Vincenzo Esposito2, Mirella Onofrio2
1Third Department of Infectious Diseases- D. Cotugno Hospital- AORN dei Colli, Naples, Italy rob.parrella@gmail.com.
Background/Aim:
HIV infection is a risk factor for re-activation of latent tubercolosis infection (LTBI). In recent years new blood tests for the detection of TB infection have been developed: Quantiferon TB Gold in Tube and TSPOT TB, which are interferon-γ releasing assays (IGRAs), have improved the identification of LTBI. In our study we have compared IGRAs and TST in HIV-positive patients with different settings of immunodeficiency.
Patients And Methods:
98 consecutive HIV patients were recruited. They underwent a blood draw, a chest radiography and a tuberculin skin test. The HIV infection setting was detected and IGRAs were carried-out. Five patients showed a complete correspondence of TST, TSPOT-TB and QFT-IT. Discordant results were observed in patients testing positive to IGRAs but negative to TST. Only 2 patients showed positive TST and negative IGRAs.
Conclusion:
Our study showed a poor concordance between tuberculin skin test and IGRAs, mainly in patients with a low CD4 cell count.
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