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Acetylsalicylic acid resistance after renal transplantation

Adam Varga1, Barbara Sandor2, Karoly Kalmar Nagy1

  • 1Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary.

In Vivo (Athens, Greece)
|January 21, 2015
PubMed

Insights

Acetylsalicylic acid (ASA) resistance is common after kidney transplants, affecting nearly 40% of patients. This resistance impacts cardiovascular disease prevention, highlighting a critical gap in post-transplant care.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Cardiovascular diseases are a major cause of death post-kidney transplant.
  • Acetylsalicylic acid (ASA) is standard preventive antiplatelet therapy.
  • Resistance to ASA is a known clinical challenge.

Purpose of the Study:

  • To assess the prevalence of ASA resistance in renal transplant recipients.
  • To identify factors associated with ASA resistance post-transplantation.

Main Methods:

  • A cohort of 214 renal transplant patients receiving 100 mg ASA daily was studied.
  • Platelet aggregation was measured using aggregometry to determine ASA resistance.
  • Logistic regression analysis examined 24 potential risk factors for resistance.

Main Results:

  • ASA resistance was identified in 40.18% of the patient cohort.
  • Resistance was associated with reduced use of statin therapy.
  • Simultaneous cyclosporine therapy was significantly increased in resistant patients.

Conclusions:

  • A significant proportion of kidney transplant patients exhibit resistance to ASA.
  • This resistance compromises a key strategy for preventing cardiovascular mortality.
  • Further research is needed to optimize antiplatelet therapy in this population.
Abstract

Keywords:
Aggregometryacetylsalicylic acid resistancecardiovascular complicationplatelet aggregationtransplantation

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