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Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease

T Shigemura1, Y Nakazawa, Y Amano

  • 1Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.

Infection
|January 21, 2015
PubMed

Insights

This case study details a rare subcutaneous infection in a patient with Chronic Granulomatous Disease (CGD) caused by the fungus Phellinus mori. It emphasizes the need to consider Phellinus species in non-Aspergillus fungal infections for CGD patients.

Area of Science:

  • Mycology
  • Immunology
  • Infectious Diseases

Background:

  • Chronic Granulomatous Disease (CGD) is a primary immunodeficiency leading to severe bacterial and fungal infections due to impaired phagocyte function.
  • Advancements in mycology have identified unique filamentous fungi as significant pathogens in CGD patients.
  • Non-Aspergillus fungal infections pose a considerable threat to individuals with CGD.

Observation:

  • A case of subcutaneous basidiomycete infection caused by Phellinus mori in a patient with CGD is presented.
  • This represents the first reported human infection by Phellinus mori.
  • The fungus was identified using morphological analysis and ribosomal RNA gene sequencing.

Findings:

  • This is the fifth reported case of filamentous basidiomycetes, specifically Phellinus species, causing infection in a CGD patient.
  • Phellinus mori was identified as the causative agent of subcutaneous infection.
  • Morphological and molecular data confirmed the fungal identification.

Implications:

  • Highlights the emerging role of Phellinus species as opportunistic pathogens in immunocompromised individuals.
  • Stresses the importance of considering Phellinus species in the differential diagnosis of non-Aspergillus fungal infections in CGD.
  • Underscores the need for enhanced diagnostic vigilance for rare fungal infections in primary immunodeficiencies.

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