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Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
drexplorer: A tool to explore dose-response relationships and drug-drug interactions
Pan Tong1, Kevin R Coombes1, Faye M Johnson1
1Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Motivation:
Nonlinear dose-response models are primary tools for estimating the potency [e.g. half-maximum inhibitory concentration (IC) known as IC50] of anti-cancer drugs. We present drexplorer software, which enables biologists to evaluate replicate reproducibility, detect outlier data points, fit different models, select the best model, estimate IC values at different percentiles and assess drug-drug interactions. drexplorer serves as a computation engine within the R environment and a graphical interface for users who do not have programming backgrounds.
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