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Updated: Apr 18, 2026
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Developing cutaneous applications of paromomycin entrapped in stimuli-sensitive block copolymer nanogel dispersions
Alba Pujol Brugués1, Beatriz Clares Naveros, Ana C Calpena Campmany
1Health Microbiology & Parasitology Department, Faculty of Pharmacy, University of Barcelona, Joan XXIII Avenue, 08028 Barcelona, Spain.
Aim:
A new paromomycin micellar nanogel based on poloxamer 407 was developed.
Materials & Methods:
In vitro release and ex vivo permeation/retention studies were conducted. In vivo tolerance was assayed by transepidermal water loss. Ex vivo cytotoxicity on RAW and VERO cells and antileishmanial activity on Leishmania promastigotes was tested.
Results:
The particle size was 9.19 nm (99% loading efficiency) exhibiting Newtonian behavior at 4°C and was pseudoplastic at 25 and 40°C. Drug release followed a Weibull model and the drug remaining in the skin was 31.652 µg/g/cm(2). In vivo tolerance achieved excellent results with negligible cellular toxicity and the best antileishmanial efficiency.
Conclusion:
The nanogel provided controlled, effective and safe delivery of paromomycin for the treatment of cutaneous leishmaniasis.
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