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Membrane transport and disease.

C A Pasternak1

  • 1St George's Hospital Medical School, London, UK.

Molecular and Cellular Biochemistry
|November 19, 1989
PubMed
Summary
This summary is machine-generated.

Disease alters membrane transport through non-specific leaks, impaired glucose transport during cellular stress, altered calcium transport in hypertension, and sodium channel dysfunction in viral infections.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathophysiology

Background:

  • Membrane transport is crucial for cellular function.
  • Dysregulation of membrane transport is implicated in various diseases.
  • Understanding these alterations is key to developing therapeutic strategies.

Purpose of the Study:

  • To review key examples of disease-induced alterations in membrane transport.
  • To highlight the molecular mechanisms underlying these transport changes.
  • To connect membrane transport defects to specific pathological conditions.

Main Methods:

  • Literature review of studies on membrane transport in disease.
  • Analysis of specific examples including pore-forming agents, glucose transporters, ion pumps, and channels.

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  • Integration of findings from biochemistry, cell biology, and clinical research.

    • Main Results:

    • Pore-forming agents can induce non-specific membrane leaks.
    • Cellular stress impacts glucose transport mechanisms.
    • Calcium-transporting ATPases (Ca2+-ATPases) are linked to hypertension.
    • Sodium (Na+) channels are affected by Herpes Simplex Virus (HSV) infection.

    Conclusions:

    • Membrane transport is a common target for pathological processes.
    • Diverse mechanisms, from leaks to channelopathies, disrupt cellular homeostasis.
    • Targeting membrane transport offers potential therapeutic avenues for various diseases.