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Determination of formulation factors that affect oral medicines acceptability in a domiciliary paediatric population

Rebecca Venables1, Hannah Batchelor2, James Hodson3

  • 1School of Pharmacy, Keele University, Keele, Staffordshire ST5 5BG, UK; Pharmacy and Therapeutics Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences (CMDS), Medical School Building, University of Birmingham, Edgbaston B15 2TT, UK.

International Journal of Pharmaceutics
|January 21, 2015
PubMed

Insights

Medicines refusal and manipulation are common in children with chronic conditions. Formulation factors like taste, texture, and volume significantly impact acceptability, necessitating age-appropriate pediatric medicines.

Area of Science:

  • Pediatric Pharmacology
  • Pharmaceutical Sciences
  • Patient Adherence

Background:

  • Acceptability of medicines in children is crucial for treatment adherence.
  • Limited research exists on formulation factors influencing pediatric medicine acceptance in home settings.

Purpose of the Study:

  • To identify the prevalence and types of oral formulation-related barriers to medicine administration in children with long-term conditions.
  • To investigate factors influencing medicine refusal and manipulation in the domiciliary environment.

Main Methods:

  • Pragmatic study utilizing semi-structured, face-to-face interviews.
  • Involved 221 parents/carers and 57 young people (aged 0-18 years) with long-term conditions.
  • Data collected on medicine administration experiences in the domiciliary setting.

Main Results:

  • Significant rates of medicine refusal (nearly one-third) and manipulation (29%) were reported.
  • Refusal was significantly associated with child's age, socioeconomic status, taste, texture, and volume.
  • Current formulations may not meet the needs of pediatric patients with chronic conditions.

Conclusions:

  • Age-appropriate pediatric medicines with acceptable taste and suitable dosage forms are required.
  • Findings highlight the need for pharmaceutical companies to prioritize pediatric formulation development.
  • Addressing formulation barriers can improve treatment adherence in children.
Abstract

Keywords:
AcceptabilityFormulationMedicinesOrganolepticPediatric

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