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Related Concept Videos

Inheritance01:25

Inheritance

2.0K
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Non-nuclear Inheritance01:29

Non-nuclear Inheritance

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5.9K
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

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Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
24.0K
Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Author Spotlight: RNAi Inheritance and ChIP in C. elegans
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Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

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Nongenetic inheritance and transgenerational epigenetics.

Moshe Szyf1

  • 1Department of Pharmacology and Therapeutics, McGill University Medical School, 3655 Sir William Osler Promenade #1309, Montreal, Quebec H3G 1Y6, Canada.

Trends in Molecular Medicine
|January 21, 2015
PubMed
Summary
This summary is machine-generated.

Inherited traits may extend beyond genetics. Parental experiences can influence offspring phenotypes through non-genetic inheritance, potentially via epigenetic mechanisms.

Keywords:
DNA methylationepigeneticsgermline transmissionhistone modificationnoncoding RNAtransgenerational

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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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Area of Science:

  • Epigenetics and Inheritance Biology

Background:

  • Genetics traditionally explains inherited traits.
  • The possibility of non-genetic inheritance of phenotypes is increasingly recognized.

Purpose of the Study:

  • To explore mechanisms of phenotype inheritance independent of genetic sequences.
  • To investigate the role of epigenetic mechanisms in multigenerational trait transmission.

Main Methods:

  • Review of recent data on behavioral and germline transmission of parental experiences.
  • Examination of proposed epigenetic mechanisms for transgenerational inheritance.

Main Results:

  • Parental experiences can be transmitted to offspring via in utero exposure or germline.
  • Epigenetic mechanisms are proposed as a key factor in multigenerational phenotype inheritance.

Conclusions:

  • Phenotypes can be inherited independently of genetic sequences.
  • Epigenetic modifications offer a plausible mechanism for transgenerational inheritance of traits and experiences.