Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GABAergic modulation of yawning behavior.

E Doger1, R Urbá-Holmgren, J R Eguibar

  • 1Departamento de Ciencias Fisiológicas, Universidad Autónoma de Puebla, Mexico.

Pharmacology, Biochemistry, and Behavior
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-life data revealed strong immunity against SARS-CoV-2 variants BA.4/BA.5 in long-term care facility residents previously infected with BA.1/BA.2.

The Journal of hospital infection·2023
Same author

Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional study.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Follicular Development and Secretion of Ovarian Hormones during the Juvenile and Adult Reproductive Lives of the Myelin Mutant <i>taiep</i> Rat: An Animal Model of Demyelinating Diseases.

International journal of endocrinology·2018
Same author

Does amnioreduction increase success of emergency cervical cerclage in cases with advanced cervical dilatation and protruding membranes?

Clinical and experimental obstetrics & gynecology·2018
Same author

Bone metastasis in endometrial cancer: evaluation of treatment approaches by factors affecting prognosis.

European journal of gynaecological oncology·2016
Same author

Does removal of CU-IUD in patients with biofilm forming candida really maintain regression of clinical symptoms?

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2014

GABAergic neurons influence rat yawning. Gamma-acetylenic-GABA increased yawning, while GABAB agonist baclofen and GABA antagonists bicuculline and picrotoxin decreased it, suggesting GABA receptor involvement in yawning behavior.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Yawning is a complex behavior with unclear neurobiological underpinnings.
  • GABAergic neurotransmission is a major inhibitory system in the brain, potentially influencing motor and arousal states.

Purpose of the Study:

  • To investigate the role of GABAergic neurons in modulating yawning behavior in rats.
  • To explore the specific involvement of GABAA and GABAB receptors in the control of yawning.

Main Methods:

  • Administration of GABA-active drugs, including GABA-T inhibitor (gamma-acetylenic-GABA), GABAB agonist (baclofen), and GABA antagonists (bicuculline, picrotoxin) in rats.
  • Intraperitoneal and subcutaneous injections of drugs to assess behavioral changes.
  • Observation and quantification of yawning frequency following drug administration.

Related Experiment Videos

Main Results:

  • Gamma-acetylenic-GABA (7 mg/kg) significantly increased yawning frequency.
  • Baclofen (3 mg/kg) completely inhibited yawning.
  • GABA antagonists, bicuculline and picrotoxin, decreased yawning frequency at subconvulsant doses.

Conclusions:

  • GABAB receptors appear to play a role in yawning behavior, potentially by modulating acetylcholine (ACh) release.
  • GABAA receptors may influence yawning frequency through inhibitory modulation of ACh neurons.
  • These findings highlight the significant role of GABAergic systems in the regulation of yawning.