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Accelerating Alzheimer's research through 'natural' animal models

Nady Braidy1, Anne Poljak, Tharusha Jayasena

  • 1aCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales bSchool of Medical Sciences, University of New South Wales cBioanalytical Mass Spectrophotometry Facility, University of New South Wales, Sydney, New South Wales, Australia dFaculty of Biological Sciences, Centre for Ageing and Regeneration (CARE), P. Catholic University of Chile, Santiago, Republic of Chile eNeuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Current Opinion in Psychiatry
|January 21, 2015
PubMed
Summary

Naturally aged animal models, like rats, dogs, and Octodon degus, show Alzheimer's disease-like symptoms. These models offer better insights into Alzheimer's disease mechanisms and therapeutic development than transgenic models.

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