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Related Experiment Video

Updated: Apr 18, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

20.7K

Response criteria for malignant lymphoma.

Anna M Maffione1, Rossella Paolini, Elisabetta Rodella

  • 1aNuclear Medicine and PET Unit bOncoematology Unit cPathology Unit dRadiation therapy Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy.

Nuclear Medicine Communications
|January 21, 2015
PubMed
Summary

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Defining treatment response criteria for malignant lymphoma has been attempted for 35 years. Lack of consensus on imaging standards hinders research and data comparison for these hematological cancers.

Area of Science:

  • Oncology
  • Radiology
  • Hematology

Background:

  • Standardized criteria for assessing malignant lymphoma treatment response are crucial for research and clinical practice.
  • Existing morphological and molecular imaging systems aim to standardize scan interpretation.
  • Despite numerous attempts over 35 years, international consensus on the most appropriate criteria is lacking.

Purpose of the Study:

  • To provide a comprehensive description of all classifications for assessing treatment response in malignant lymphoma.
  • To highlight the ongoing lack of consensus among international hematological associations.
  • To stimulate discussion and focus attention on the need for standardized assessment criteria.

Main Methods:

  • Review and detailed description of various classification systems for malignant lymphoma treatment response.

Related Experiment Videos

Last Updated: Apr 18, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

20.7K
  • Analysis of morphological and molecular imaging approaches.
  • Comparative overview of existing criteria and their limitations.

    • Main Results:

    • Multiple classification systems have been developed over the past 35 years.
    • These systems aim to standardize interpretation, facilitate multicentric trials, and enable data comparison.
    • A significant lack of consensus persists among major international hematological associations regarding the optimal criteria.

    Conclusions:

    • The absence of a universally accepted standard for evaluating lymphoma treatment response remains a challenge.
    • A unified approach is needed to improve the reliability and comparability of research findings.
    • Further efforts are required to establish consensus on the most effective imaging-based criteria.