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[Effects of exercise and diet intervention on oxidative stress in insulin resistant rat]
Qingyan Sun1, Fenfen He, Miaomiao Li
1College of Life Science, Anhui Normal University, Wuhu 241000, China. sunqingyan1975@126.com
Objective:
To investigate the effects of exercise, diet and their combination intervention on oxidative stress of insulin resistance rat.
Methods:
Establish obesity-induced insulin resistance rat models. Obesity was assessed by the body weight and lipid ratio. Glucose tolerance was assessed by the integrated area under the curve for glucose (AUCg) during an oral glucose tolerance test (OGTT), then 8 weeks of exercise, diet, and combination interventions, respectively. To analyze serum free fatty acids (FFA) content, superoxide dismutase (SOD) and maleic dialdehyde (MDA) content in liver, adipose tissue and soleus muscle by biochemical method. Judge oxidative stressby FFA content and SOD/MDA.
Results:
Three kinds of intervention reduced the body weight (P < 0.01), lipid ratio (P < 0.01) and AUCg (P < 0.01). Dietary and combination intervention lowered serum free fatty acid concentration (P < 0.01), separate exercise intervention had not such effect. Three kinds of intervention increased SOD/MDA in the liver and adipose tissue, exercise and combination intervention improved SOD/MDA in soleus muscle, dietary intervention alone had not the effect.
Conclusion:
Exercise and dietary intervention may improve the overall insulin resistance by alleviating oxidative stress.
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